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Vaccinating Against an HIV Rebound

New research has raised expectations that an effective HIV vaccine is on the horizon. But it has also heightened concerns that so-called rebound effects – like the re-emergence of practices that expose people to HIV infection – will pose new challenges in the decades-long struggle to eliminate the virus.

BRIGHTON – When I began my career as an HIV activist in Botswana two decades ago, the thought of a vaccine seemed fanciful. Even after the country hosted vaccine trials in the mid-2000s, many of us on the frontlines of the fight against HIV doubted that such a breakthrough would ever happen.

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